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Zoloft should not be taken if you are already taking pimozide (Orap), or an MAO inhibitor like isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam). Severe side effects can occur if Zoloft is taken in combination with the mentioned medications. There should be a minimum of 14 days gap between discontinuation of MAO inhibitor and start of Zoloft medication period and vice versa.
Prior to starting the medication, you must inform your physician if you have any of the following conditions: - liver or kidney problems; - seizures or epileptic disorder; - bipolar disorder (manic depression); or - previous record of addiction or suicidal tendency. In case of having any of these conditions, either Zoloft should not be prescribed to you or the amount of dosage has to be administered carefully with some special tests.
Patients who are less than 24 years old may develop suicidal tendency at the initial stage of antidepressant medication. Inform your physician if you come across suicidal thoughts within the first few weeks of medication.
Family and other people around the patient need to be careful about any sudden change of patient’s mood or symptoms. The physician also needs to observe the patient frequently for at least first 3 months of Zoloft medication.
Women who are pregnant or planning to have child should not be treated with Zoloft, as antidepressants are likely to create lung complexities of newborn children. Never give the drug or anybody under 18 years of age without recommendation of a physician. Zoloft is not approved by FDA to treat depressive disorders of children.